Secoisolariciresinol diglucoside(Synonyms: 亚麻木酚素; (S,S)-SDG; (S,S)-LGM2605)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Secoisolariciresinol diglucoside;(Synonyms: 亚麻木酚素; (S,S)-SDG; (S,S)-LGM2605) 纯度: 99.94%

Secoisolariciresinol diglucoside ((S,S)-SDG) 是全麦亚麻籽中的主要木脂素，具有抗炎，抗氧化，抗诱变，抗微生物，抗肥胖，降血脂和神经保护作用。

Secoisolariciresinol diglucoside(Synonyms: 亚麻木酚素; (S,S)-SDG; (S,S)-LGM2605)

Secoisolariciresinol diglucoside Chemical Structure

CAS No. : 257930-74-8

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ￥1209 In-stock
5 mg ￥800 In-stock
10 mg ￥1400 In-stock
25 mg ￥2800 In-stock
50 mg ￥3900 In-stock
100 mg ￥6700 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

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Secoisolariciresinol diglucoside 相关产品

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生物活性

Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects[1][2].

体外研究
(In Vitro)

Secoisolariciresinol diglucoside (1-500 μM) possesses strong reducing power and high free radical scavenging activity for hydroxyl, peroxyl and DPPH free radicals[1].
Secoisolariciresinol diglucoside (1-50 μM; 24 h) attenuates human monocyte adhesion to and migration across human brain endothelial monolayers[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Secoisolariciresinol diglucoside (4 mg/mouse; a single p.o.) diminishes leukocyte adhesion and migration across blood-brain barrier (BBB) in neuroinflammation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hand feeding mice (10 weeks old, male) are injected with TNFα[2]
Dosage: 4 mg/mouse
Administration: P.o. 2 h before i.c. administration of TNFα
Result: Attenuated adhesion of leukocytes to the endothelium by 50% and attenuated migration of leukocytes across the BBB by 64%.

分子量

686.70

Formula

C32H46O16
CAS 号

257930-74-8
中文名称

亚麻木酚素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : ≥ 100 mg/mL (145.62 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4562 mL 7.2812 mL 14.5624 mL
5 mM 0.2912 mL 1.4562 mL 2.9125 mL
10 mM 0.1456 mL 0.7281 mL 1.4562 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Mishra OP, et al. Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorg Med Chem Lett. 2013 Oct 1;23(19):5325-8.

    [2]. Rom S, et, al. Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation. J Neuroinflammation. 2018 Jan 27;15(1):25.