Azure B(Synonyms: Azure B chloride)

发表于由

Azure B;(Synonyms: Azure B chloride) 纯度: 96.08%

Azure B 是一种阳离子染料 (cationic dye)，是 Methylene blue 的主要代谢物，用于 Azure 曙红染色剂以进行血液涂片染色。Azure B 是一种高效、选择性和可逆的抑制单胺氧化酶 (MAO)-A 的抑制剂，对重组人的 MAO-A 和 MAO-B 的IC50 分别为 11 和 968 nM。Azure B 具有显著的抗抑郁作用。

Azure Bamp;;(Synonyms: Azure B chloride)

Azure B Chemical Structure

CAS No. : 531-55-5

规格 价格 是否有货 数量
5 mg ￥5500 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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Azure B 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Neuronal Signaling Compound Library
  • Reprogramming Compound Library
  • Anti-Parkinson’s Disease Compound Library
  • Neurodegenerative Disease-related Compound Library
  • Mitochondria-Targeted Compound Library

生物活性

Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects[1][2].

体内研究
(In Vivo)

Azure B (4-30 mg/kg; i.p.; once) decreases immobility in the forced swim test (FST)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

305.83

Formula

C15H16ClN3S
CAS 号

531-55-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. Löhr W,et al. The azure dyes: their purification and physicochemical properties. II. Purification of azure B. Stain Technol. 1975 May;50(3):149-56.

    [2]. Delport A, et al. Azure B and a synthetic structural analogue of methylene blue, ethylthioninium chloride, present with antidepressant-like properties. Life Sci. 2014 Nov 11;117(2):56-66.