R18 TFA;(Synonyms: PHCVPRDLSWLDLEANMCLP TFA) 纯度: 98.35%
R18 TFA 是 14-3-3 的肽拮抗剂，其KD 值为 70-90 nM。R18 可有效阻断14-3-3 与其配体Raf-1激酶的结合，可有效地消除14-3-3对磷酸酶诱导的Raf-1失活的保护作用。
R18 TFA Chemical Structure
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 5 mg | ￥3500 | In-stock | |
| 10 mg | ￥6000 | In-stock | |
| 50 mg | ; | 询价 | ; |
| 100 mg | ; | 询价 | ; |
* Please select Quantity before adding items.
R18 TFA 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- Peptide Library
| 生物活性 |
R18 TFA is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1[1]. |
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| 分子量 |
2423.73 |
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| Formula |
C103H158F3N27O31S3 |
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| Sequence |
Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro |
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| Sequence Shortening |
PHCVPRDLSWLDLEANMCLP |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Sealed storage, away from moisture
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture) |
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| 溶解性数据 |
In Vitro:;
H2O : < 0.1 mg/mL (ultrasonic) (insoluble) |
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| 参考文献 |
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