Fibronectin Adhesion-promoting Peptide(Synonyms: Heparin Binding Peptide)

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Fibronectin Adhesion-promoting Peptide;(Synonyms: Heparin Binding Peptide) 纯度: 99.13%

Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) 是一种肝素结合氨基酸序列，这段序列存在于纤连蛋白 C-端的肝素结合域中。Fibronectin Adhesion-promoting Peptide 促进间充质干细胞 (MSC) 球状体组装成更大的聚集体。Fibronectin Adhesion-promoting Peptide 通过与细胞的肝素结合区反应直接促进内皮细胞的粘附、扩散和迁移。

Fibronectin Adhesion-promoting Peptideamp;;(Synonyms: Heparin Binding Peptide)

Fibronectin Adhesion-promoting Peptide Chemical Structure

CAS No. : 125720-21-0

规格 价格 是否有货 数量
5 mg ￥2400 In-stock
10 mg ￥3800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Fibronectin Adhesion-promoting Peptide 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Macrocyclic Compound Library
  • Peptide Library

生物活性

Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates. Fibronectin Adhesion-promoting Peptide directly promotes the adhesion, spreading, and migration of endothelial cells by reacting with heparin binding domains of cells[1][2].

体外研究
(In Vitro)

GRGDS and Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide: WQPPRARI) micropatterns increase the endothelialisation of prosthetic materials in vitro. Fibronectin Adhesion-promoting Peptide also enhances haptotactic cell migration. The anti-apoptotic effects of fibronectin require the presence of the WQPPRARI sequence, which may be due to synergistic survival signals mediated by this sequence and by the RGD motif[1].
RDGS and Fibronectin Adhesion-promoting Peptide promote cell adhesion through different activation pathways that induce different forms of adhesion which can be highlighted through the analysis of focal and fibrillar contacts[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1023.19

Formula

C47H74N16O10
CAS 号

125720-21-0
Sequence

Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile
Sequence Shortening

WQPPRARI
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 2 mg/mL (1.95 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9773 mL 4.8867 mL 9.7734 mL
5 mM — — —
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Hoesli CA, et al. A fluorophore-tagged RGD peptide to control endothelial cell adhesion to micropatterned surfaces. Biomaterials. 2014 Jan;35(3):879-90.

    [2]. Chollet C, et al. Impact of peptide micropatterning on endothelial cell actin remodeling for cell alignment under shear stress. Macromol Biosci. 2012 Dec;12(12):1648-59.

    [3]. Lei J, Murphy WL, et al. Combination of Heparin Binding Peptide and Heparin Cell Surface Coatings for Mesenchymal Stem Cell Spheroid Assembly. Bioconjug Chem. 2018 Apr 18;29(4):878-884.