GLP-1(32-36)amide,一种衍生自糖调节激素 GLP-1 的 C 末端的五肽。GLP-1(32-36)amide 可抑制糖尿病小鼠的体重增加并调节全身葡萄糖代谢。
GLP-1(32-36)amide Chemical Structure
CAS No. : 1417302-71-6
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5 mg
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10 mg
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50 mg
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GLP-1(32-36)amide 相关产品
bull;相关化合物库:
Bioactive Compound Library Plus
GPCR/G Protein Compound Library
Diabetes Related Compound Library
Peptide Library
生物活性
GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice[1][2].
体外研究 (In Vitro)
GLP-1(32-36)amide (0.1-10 μM; 24 h) retains cell viability and decreases apoptosis against Streptozotocin (STZ; 1 μM) in INS‐1 cells[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay[2]
Cell Line:
INS‐1 cells
Concentration:
0.1, 1, 10 μM
Incubation Time:
24 hours
Result:
Decreased cell viability only approximately 30% in 0.1 μM and approximately 20% in ≥1 μM while approximately 45% in saline-treated controls.
体内研究 (In Vivo)
GLP-1(32-36)amide (1 μmol/kg; i.p. once daily for 21 d) protects islet from damage, inhibits weight gain, and relieves symptoms of polydipsia in diabetic mice[2]. GLP-1(32-36)amide (1 μmol/kg; a single i.p.) slightly reduces the mean glucose lever at 30 min after the challenge of glucose in normal mice[2]. GLP-1(32-36)amide (50-70 nmol/kg/d; infusion for 12-16 weeks) prevents the development of diet-induced obesity and hepatic steatosis in high fat-fed mice[3].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
Male KM mice (6-8 weeks; 18-22 g) injected with STZ[2]
Dosage:
1 μmol/kg
Administration:
I.p. once daily for 21 days
Result:
Significantly lowered the cumulative values of food and water intake. Lowered fasting glucose. Reduced the level of Hemoglobin A1c (HbA1c). Improved glucose tolerance. Suppressed body weight gain.
分子量
570.73
Formula
C25H50N10O5
CAS 号
1417302-71-6
Sequence
Leu-Val-Lys-Gly-Arg-NH2
Sequence Shortening
LVKGR-NH2
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Elahi D, et, al. GLP-1(32-36)amide, a novel pentapeptide cleavage product of GLP-1, modulates whole body glucose metabolism in dogs. Peptides. 2014 Sep;59:20-4.
[2]. Sun L, et, al. Novel Pentapeptide GLP-1 (32-36) Amide Inhibits β-Cell Apoptosis In Vitro and Improves Glucose Disposal in Streptozotocin-Induced Diabetic Mice. Chem Biol Drug Des. 2015 Dec;86(6):1482-90.
[3]. Tomas E, et, al. GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice. Diabetes. 2015 Jul;64(7):2409-19.