D-JBD19

D-JBD19; 纯度: 99.84%

D-JBD19 是一种不可渗透性的多肽。D-JBD19 具有神经保护作用。

D-JBD19amp;;

D-JBD19 Chemical Structure

CAS No. : 954134-42-0

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10 mg ¥8800 In-stock
50 mg ¥25000 In-stock
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D-JBD19 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

D-JBD19 is a non-permeable peptide[1]. D-JBD19 has neuroprotective effects[2].

体外研究
(In Vitro)

D-JBD19 is a non-permeable cargo corresponding to dJNKi peptide[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Neuroprotective effects of D-JBD19 against middle cerebral artery occlusion (MCAO) as compared with D-JNKI1. 15.7 ng of either D-JBD19 or D-JNKI1 or 1570 ng of D-JBD19 are injected i.c.v. just after the ischemia. Animals were killed 24 h later. 100 times more D-JBD19 is needed to provide protection than with D-JNKI1[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2250.56

Formula

C99H164N32O28

CAS 号

954134-42-0

Sequence

Asp-Gln-Ser-Arg-Pro-Val-Gln-Pro-Phe-Leu-Asn-Leu-Thr-Thr-Pro-Arg-Lys-Pro-Arg

Sequence Shortening

DQSRPVQPFLNLTTPRKPR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)

参考文献
  • [1]. Cardozo AK, et al. Cell-permeable peptides induce dose- and length-dependent cytotoxic effects. Biochim Biophys Acta. 2007 Sep;1768(9):2222-34.

    [2]. Vaslin A, et al. Excitotoxicity-induced endocytosis mediates neuroprotection by TAT-peptide-linked JNK inhibitor. J Neurochem. 2011 Dec;119(6):1243-52.