740 Y-P TFA;(Synonyms: 740YPDGFR TFA; PDGFR 740Y-P TFA)
740 Y-P TFA (740YPDGFR; PDGFR 740Y-P) 是一个有效的，具有细胞渗透性的 PI3K 激活剂。740 Y-P TFA 很容易结合含有 p85 的 N- 和 C- 末端 SH2 结构域的 GST 融合蛋白，但不能单独结合 GST。
740 Y-P TFA Chemical Structure
| 规格 | 是否有货 | ||
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| 100 mg | ; | 询价 | ; |
| 250 mg | ; | 询价 | ; |
| 500 mg | ; | 询价 | ; |
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740 Y-P TFA 的其他形式现货产品:
| 生物活性 |
740 Y-P TFA is a potent and cell-permeable PI3K activator. 740 Y-P TFA readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone[1]. |
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| 体外研究 (In Vitro) |
740 Y-P TFA (50 μg/ml; 48 hours) specificly stimulates mitogenesis in medium is better than EGF or FGF at stimulating entry into S-phase, it shows the percentage of cells in S-phase for 48.3% in C2 cells. Additionally, LY294002 or wortmannin potently inhibits the mitogenic response stimulated by the 740 Y-P TFA peptide[1].740 Y-P TFA (1 μg/mL) stimulates mitogenesis at the lowest concentration tested. The peptide stimulates mitogenesis in both the presence and absence of serum (0.5%), and in the former instance a maximal response observed at 50 μg/mL. 740Y-P to stimulate mitogenesis is highly specific and not a general feature of a cell permeable SH2 domain binding peptides[1].740 Y-P TFA (30 μM; 24 hours) remarkably inhibits the level of LC3-II/LC3-I in GO-induced PC12 cells[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[2]
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| 分子量 |
3384.72 |
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| Formula |
C143H223N43F3O41PS3 |
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| Sequence Shortening |
RQIKIWFQNRRMKWKKSDGG-{PO2Y}-MDMS |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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