MM 54;
MM 54 (compound 5) 是竞争性的 APJ 拮抗剂，其 IC50 值为 93 nM。MM 54作为一种有效的和选择性的 apelin 结合和 APLNR 激活的抑制剂。
MM 54 Chemical Structure
CAS No. : 1313027-43-8
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| 生物活性 |
MM 54 (compound 5) is a competitive antagonist at APJ, with an IC50 of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation[1][2]. |
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| 体外研究 (In Vitro) |
MM 54 inhibits more than 95% of apelin binding to APLNR at the dose of 10 µM[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 体内研究 (In Vivo) |
MM 54 (2 mg/kg, ip, bi-weekly for 4 weeks) possesses anti-tumor activity in glioblastoma models with no obvious toxicity[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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| 分子量 |
1737.17 |
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| Formula |
C70H121N29O15S4 |
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| CAS 号 |
1313027-43-8 |
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| Sequence Shortening |
CRPRLCKHCRPRLC (Disulfide bridge:Cys1-Cys6; Cys9-Cys14) |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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